Quezon City is located at the heart of Metro Manila, towards its northeastern portion.  It is bordered by Manila to the southwest, by Caloocan City and Valenzuela City to the west and northwest.  Towards the south, lies San Juan and Mandaluyong City, while Marikina City and Pasig City borders Quezon City to the southeast. Towards the north, across Marilao River, lies San Jose del Monte City in the province of Bulacan, and towards the east, lies Rodriguez and San Mateo, both in the province of Rizal.

 Quezon City is also its strategic convergence point for the metropolitan road and transportation networks, making the City an ideal distribution hub.  It is easily accessible from the major highways, thoroughfares and mass transit systems of Metro Manila.  The city is traversed by several major metropolitan thoroughfares, namely Circumference Road-3 or C-3 (Araneta Avenue), C-4 (most of EDSA), C-5 (Katipunan - Luzon - Republic Avenue), R-6 (Aurora Blvd.), R-7 (Quezon Avenue - Commonwealth Avenue) and R-8 (Bonifacio Avenue - Quirino Highway), which provide numerous linkages of  the city to the rest of Metro Manila.

 More than 2 million vehicles a day ply EDSA, which is the main circumferential road and highway of Metro Manila in the Philippines.  This highway is named in honor of Epifanio de los Santos, a noted Filipino historian.   It is an important commuting artery between the northern and southern parts of the metropolitan area.   EDSA is mostly a 10-lane divided highway (expressway) with interchanges along its length that eliminate the need for traffic lights, though traffic lights exist where there is insufficient space or funds for a complete interchange. Stretching some 24 kilometers, it is one of the longest avenues in the Philippines, and its longest expanse is in Quezon City.

 Commonwealth Avenue, formerly called Don Mariano Marcos Avenue, is the widest highway in the country, with a length of 12.4 kilometers and spanning 10 to 18 lanes. It starts from the Quezon Memorial Circle inside the Elliptical Road, and passes through the areas of Philcoa, Tandang Sora, Balara, Batasan Hills, and ends at Mindanao Avenue in the Fairview area.

An important recent development is the development of Segment 8.1 or the NLEX Mindanao Avenue Link, a 2.7-kilometer expressway that provides motorists with additional entry and exit ramps from Quezon City to the North Luzon Expressway (NLEX).  This new roadway dramatically speeds up the transport of people and goods via the NLEX and thereby, help further connect the developments of Quezon City to Central and Northern Luzon, enhancing the city’s position as an important gateway.

These thoroughfares are supplemented by main and secondary intra-city roads for area-wide mobility and by numerous tertiary roads.  Mass rail transportation system nodes are most numerous in Quezon City, compared to other cities of Metro Manila.  The Metro Rail Transit (MRT), Line 3 of the metropolis' railway system, runs along most of EDSA, and connects Quezon City to Manila.  The Light Rail Transit (LRT), Line 1, runs from the EDSA - North Avenue intersection in Quezon City to the Monumento roundabout in Caloocan City.  The Light Rail Transit (LRT), Line 2 can be seen along the intersection EDSA and the rail line's path, Aurora Boulevard in Quezon City, producing another convenient link to the other metro cities.

The Manila Red Line or Mass Rapid Transit Line 7 (Red Line/MRT-7) will connect Quezon City to Bulacan.  When completed, the line will be 23 km long with 14 stations, and will run in a northeast direction, traversing Quezon City and a part of Caloocan City in Metro Manila before ending at the City of San Jose del Monte in Bulacan province. Passengers will be able to transfer to the Yellow Line and Blue Line through the Metro Manila Integrated Rail Terminal that will link the three lines at North Avenue in Quezon City.